Novel methods to deal with publication biases : secondary analysis of antidepressant trials in the FDA trial registry

نویسندگان

  • Alex J Sutton
  • Erick H Turner
چکیده

Objective To assess the performance of novel contour enhanced funnel plots and a regression based adjustment method to detect and adjust for publication

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A test for reporting bias in trial networks: simulation and case studies

BACKGROUND Networks of trials assessing several treatment options available for the same condition are increasingly considered. Randomized trial evidence may be missing because of reporting bias. We propose a test for reporting bias in trial networks. METHODS We test whether there is an excess of trials with statistically significant results across a network of trials. The observed number of ...

متن کامل

Efficacy and effectiveness of antidepressants: current status of research.

BACKGROUND This paper examines the current status of research on the efficacy and effectiveness of antidepressants. METHODS This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug Administration (FDA) and analyzes STAR*D (Sequenced Treatment Alternatives to Relieve Depression), the largest antidepressant effectiveness trial ever conducted. RESULTS Meta-...

متن کامل

Clinical trials registries are under-utilized in the conduct of systematic reviews: a cross-sectional analysis

BACKGROUND Publication bias is a major threat to the validity of systematic reviews. Searches of clinical trials registries can help to identify unpublished trials, though little is known about how often these resources are utilized. We assessed the usage and results of registry searches reported in systematic reviews published in major general medical journals. METHODS This cross-sectional a...

متن کامل

Association of the FDA Amendment Act with trial registration, publication, and outcome reporting

BACKGROUND Selective clinical trial publication and outcome reporting has the potential to bias the medical literature. The 2007 Food and Drug Administration (FDA) Amendment Act (FDAAA) mandated clinical trial registration and outcome reporting on ClinicalTrials.gov, a publicly accessible trial registry. METHODS Using publicly available data from ClinicalTrials.gov, FDA documents, and PubMed,...

متن کامل

تصادفی سازی در مطالعات کارآزمایی بالینی: از تئوری تا عمل

Background & Aim: Randomized clinical trials (RCTs) are studies which are able to provide the most valid evidence to compare various interventions in health research. Biases can affect the quality of research and ultimately make the results of a study invalid. One of the most important biases is selection bias. The best way to reduce selection bias is the use of random allocation. The aim of th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009